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The depletion of all FAPα-expressing fibroblasts led to a substantial reduction in the number of cells in the synovial membrane, suggesting a general reduction in inflammation.

Synovitis is a condition of the synovial membrane, which lines the cavities of the joints.

Every diarthrodial joint possesses a fibrous or ligamentous capsule, lined with synovial membrane, attached to the adjacent ends of the articulating bones.

In structure, they are analogous to synovial membranes, and secrete a similar fluid.

Occasionally the ends of the bones, where they are covered by the synovial membrane of the joints, are dotted with tubercles.