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“I sell many good oils for cleaning, tinctures for rheumatism, plague, soreness, warts, and bad luck.”

A large, robust, athletic man, Washington was plagued by headaches, stomach troubles, and bouts of rheumatism—a painful condition affecting the joints such as knees and elbows.

Significantly, bone related diseases like osteoporosis, rheumatism and periodontitis are associated hyper activation of bone resorption by osteoclast.

He had faked deafness, rheumatism, and heart trouble.

Through the 19th century, the psychoactive drug derived from some varieties of the plant was often used in medicines and cure-alls that claimed to alleviate various conditions including rheumatism and melancholia.