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Concurrently, the biocatalysis cycle using a PLP enzyme modifies the amino acid substrate via a series of activation steps unique to PLP biochemistry.

“I was facing allegations of child abuse and first-degree murder of my 5-month-old son,” Tom Imschweiler wrote to PLP from a North Carolina prison.

Known as a protein-like polymer, or PLP, the synthetic material is designed to bind to proteins as if it were itself a protein.

This particular PLP is structured to alter the interaction between Nrf2 and another protein called Keap1.

Jeffrey Johnson says he was initially somewhat skeptical about the PLP approach, given his unfamiliarity with it and the general difficulty of precisely targeting proteins in brain cells.