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Symptoms of the condition include irritability, making death threats to complete strangers, screaming at relatives, arguing with mirrors, excessive weight gain, poor hygiene and mental confusion.

"The lack of sleep, irritability, brain fog - she'd be awake for hours in the night, hot sweats every single day. Everything was becoming difficult."

On the flip side, feeling "hangry" – the phenomenon where hunger manifests in the form of anger or irritability – illustrates how what we eat, or don't eat, can also provoke negative emotions.

An autopsy determined that he died of hyperthermia, a dangerous internal overheating that can cause confusion, irritability and a lack of coordination.

Her symptoms included weight loss, fatigue, tremors, a rapid heart rate — and irritability.