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In the most detailed analysis to date, they demonstrated that the molecular pathway most responsible for the cancer-driving functions of KRASis highly dependent on a protein called ERK that has dual functions in regulating which genes are expressed and which proteins are active.

Indeed, a core finding of the Science papers was that activation of the ERK protein alone is the key driver of resistance to drugs that inhibit KRAS.

Taking advantage of improved methods to study cellular signaling, the researchers demonstrated that the ERK protein regulates the expression of a remarkably complex array of thousands of genes and changes the activity of thousands of proteins.

“Erk is an unusual name, though. How did you come up with it?”

“Wood Yoomove Erk, that’s his name?”