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Then, in the summer of 1991, a catastrophic train derailment just north of town spilled nearly 20,000 gallons of a highly toxic herbicide into the Sacramento River.

Women have two X chromosomes, while males have X and Y, meaning the appearance of the gene can be more catastrophic in male pregnancies.

That would be "catastrophic for our business," Le says.

Calling this a constitutional crisis undersells the catastrophic implications of the emergency.

Isaiah suffered "catastrophic" brain damage after being deprived of oxygen at birth and died in March 2018.