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"In this way, p53 is very effective in preventing carcinogenesis," explains Strebhardt.

The latest results make him very optimistic that the tide could finally turn in the treatment of ovarian carcinomas. "p53 mRNA is not a normal therapeutic that targets a specific weak point in cancer cells. Instead, we are repairing a natural mechanism that the body normally uses very effectively to suppress carcinogenesis. This is a completely different quality of cancer therapy."

"The fact that epimutations might be happening early during pregnancy challenges conventional theories on carcinogenesis and cancer risk. Moreover, the fact that they occur twice as common in girls than boys reveal an important gender difference not previously recorded," says Lønning.

Dr. Kon concludes by saying, "This study further brings forth the prospect that cell competition constrains the order of appearance of mutations during tumor development, highlighting a link between cell competition and carcinogenesis. We hope that this will pave the way for the development of new cancer treatments from the standpoint of cell competition and infiltration for the benefit of our society."

"Many don’t know that the World Health Organization has classified bacon in the same category as tobacco when it comes to carcinogenesis," says Reyzan Shali, MD, referring to the process by which normal cells are transformed into cancer cells.