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When the two examined the sequence, they found a mutation in a gene, CALM2, encoding a protein called calmodulin whose misfunction had already been implicated in heart arrythmias and disorders and even deaths in infancy.

He realized that a patient registry he oversaw had a family that mirrored the Folbigg situation: a healthy mother with a similar mutation in a gene for another calmodulin, who had two kids that suffered heart attacks, with one dying.

One proposed idea is that stimulus-specific temporal patterns of cytoplasmic Ca2+ levels might provide a key cue, and that these ‘Ca2+ signatures’ might be generated and decoded by specific Ca2+-binding components, such as calmodulin proteins or calcium-dependent protein kinases8.

Sakaba, T. & Neher, E. Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse.