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A calando — a direction to gradually diminish — is stretched over several measures, then the words “molto più” are written above a final measure before a section labeled “tempo giusto,” with a metronome marking of “circa 46.”

Last year scientists led by Mark Davis at the California Institute of Technology, who is a founder of Calando Pharmaceuticals, published a paper in Nature demonstrating the first proof of RNAi delivered through the bloodstream working in humans.

"We're excited about it because there is a lot of skepticism whenever any new technology comes in," said Davis, a consultant to privately held Calando Pharmaceuticals Inc, which is developing the therapy.

A climax is finally reached, in measure 224, with a fortissimo statement of the chief theme of the prelude, and then, after this has cooled down, diminuendo e calando, the second theme enters in the home key.

Tutti was the great-uncle of the infamous Con Spirito, well known to posterity as the lover of the lovely but passionate Violenza Allargando, destined to become the mother of Largo con Craviata, the fearless captain of Dolcissimo's light horse under General Lamento Agitato, whose grandmother, Sempre Calando, was notorious for her illicit liaison with Pesante e Stentato, a union which was to bear fruit in the shape of Lusingando Molto.